Oral Therapies for Erectile Dysfunction

Convenient. Familiar. Clinically Proven.

FDA-Approved Oral Medications for ED

Several oral prescription medications are FDA-approved to treat erectile dysfunction.
These medications work by relaxing smooth muscle and increasing blood flow to the penis during sexual stimulation.

Approved oral therapies include:

  • Avanafil (Stendra)
  • Sildenafil (Viagra / Generic Sildenafil)
  • Tadalafil (Cialis / Generic Tadalafil)
  • Vardenafil (Levitra, Staxyn)

While these medications function similarly, differences exist in onset time and duration.

MECHANISM OF ACTION

How Oral ED Medications Work

Oral ED medications belong to a class of drugs called PDE5 inhibitors.

They work by:

  • Enhancing blood flow to the penis
  • Supporting the natural erectile response
  • Requiring sexual stimulation to be effective

These medications do not automatically cause an erection — stimulation is still required. They do not cure erectile dysfunction or increase sexual desire.

Sildenafil

Sildenafil is one of the most widely used oral treatments for erectile dysfunction.

Typical Characteristics:

  • Onset: 30–60 minutes
  • Duration: 4–6 hours
  • Taken as needed before sexual activity
  • Typically not taken more than once in 24 hours

Sildenafil can be taken with or without food, though high-fat meals may delay onset.

TADALAFIL

Tadalafil offers a longer duration of action compared to other oral ED medications.

Typical Characteristics:

  • Onset: 30–45 minutes
  • Duration: Up to 36 hours
  • Can be taken daily or as needed
  • Often referred to as the “weekend option”

Daily dosing allows for greater spontaneity, while as-needed dosing provides flexibility.

Tadalafil can be taken with or without food, though high-fat meals may delay absorption.

DOSING OPTIONS

Daily or As Needed?

Tadalafil may be prescribed in two ways:

Daily Dosing:

  • Lower daily dose.
  • Maintains consistent levels in the bloodstream.
  • Allows sexual activity at any time.

As-Needed Dosing:

  • Taken before anticipated activity
  • Not more than once per day

Your provider will determine which approach aligns best with your health profile and goals.

Important Safety Information

Oral ED medications should not be taken with nitrate medications, including:

  • Nitroglycerin
  • Isosorbide dinitrate
  • Isosorbide mononitrate

Combining these medications can cause a dangerous drop in blood pressure.

Additional considerations:

  • Avoid recreational nitrates (“poppers”)
  • Inform your provider of all medications and supplements
  • Disclose any cardiovascular conditions
  • Inform emergency providers

if you have taken an ED medication
Sexual activity can place strain on the heart. If you experience chest pain, dizziness, or nausea during activity, seek medical attention.
All medication decisions should be guided by a licensed healthcare provider.

Who May Prefer Oral Therapy?

  • Men with mild to moderate ED
  • Men who prefer a non-invasive option
  • Men new to ED treatment
  • Men seeking a convenient tablet form

Oral therapy remains an effective first-line option for many patients.

Oral Therapy or Injection Therapy?

Both oral and injection therapies are clinically appropriate options.
Oral therapy offers convenience and familiarity.

Injection therapy offers a more direct, localized approach.

Your provider will consider:

  • Medical history
  • Response to prior treatments
  • Comfort level
  • Performance goals

There is no universal “best” therapy — only what is best for you.

Need More Predictable Results?

Injection therapy offers a fast, localized approach that many men prefer when timing and reliability matter most.

Ready to Explore Your Options?

Effective treatment begins with the right evaluation.